Do CAD genetic risk scores predict cardiovascular risk?

CAD genetic risk scores (GRSs) predict risk independently from clinical tools, like QRISK3. We assessed the added value of GRSs for a variety of cardiovascular traits (CV GRSs) for predicting CAD and MACE and tested their early-life screening potential by comparing against the CAD GRS only.

Is CAD genetic risk stratification a good idea?

Coronary artery disease (CAD) and major adverse cardiovascular events (MACE) are the leading causes of death in the general population, but risk stratification remains suboptimal. CAD genetic risk scores (GRSs) predict risk independently from clinical tools, like QRISK3.

Can human expertise improve the diagnosis of CAD?

The results of this study demonstrate the potential for this approach to improve the diagnosis of CAD and highlight the importance of considering the role of human expertise in the development of computer-aided classification models.

What is CAD risk score 1 & 2?

As described in Supplemental Methods, score 1 was QRISK3. Score 2 comprised QRISK3, the CAD GRS, 10 the genetic array, and the fifth and ninth principal components, as they independently contributed to CAD risk ( Table 2 ).